Rab32 Modulates Apoptosis Onset and Mitochondria-associated Membrane
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چکیده
Michael Bui, Susanna Y. Gilady, Ross E. B. Fitzsimmons, Matthew D. Benson, Emily M. Lynes, Kevin Gesson, Neal M. Alto, Stefan Strack, John D. Scott , and Thomas Simmen From the Department of Cell Biology, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta T6G 2H7, Canada, the Department of Microbiology, University of Texas Southwestern, Dallas, Texas 75390, the Department of Pharmacology, School of Medicine, University of Washington, Seattle, Washington 98195-7280, and the Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242
منابع مشابه
Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties.
The mitochondria-associated membrane (MAM) has emerged as an endoplasmic reticulum (ER) signaling hub that accommodates ER chaperones, including the lectin calnexin. At the MAM, these chaperones control ER homeostasis but also play a role in the onset of ER stress-mediated apoptosis, likely through the modulation of ER calcium signaling. These opposing roles of MAM-localized chaperones suggest ...
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تاریخ انتشار 2010